Cannabis abuse during adolescence increases the risk of developing psychosis and prefrontal cortex (PFC)-dependent cognitive deficits later in life. The CB1 cannabinoid receptor has long been known to mediate the psychoactive effects of cannabis, yet the mechanisms underlying such vulnerability remain unknown. Here, I will discuss data from my lab and others showing that long-lasting deficits in prefrontal functions can occur following repeated exposure to cannabinoids during adolescence. We recently found conclusive evidence that early and mid-adolescence are unique developmental periods during which the cannabinoid system interacts with PFC maturation. Data indicate that too much CB1 receptor stimulation during adolescence can arrest the development and maturation of PFC functional capacity. Together, these findings are directly applicable not only to natural cannabinoids, but also to the new generation of synthetic, easily-obtainable, and more potent CB1 receptor agonists (e.g., JWH-018, CP47,497) currently available legally and illegally all over the world.
C2ST Speakeasy is held on the first and third Tuesdays of every month. Attendance is free, but registration is strongly encouraged. To register, click HERE or on the “Get Tickets” button below. Seating is first come, first serve, and registration does not guarantee a seat.
This program is presented in partnership with SFCO (formerly Geek Bar Chicago) and the Chicago Society for Neuroscience
People under 21 are welcome at SFCO until 9:00pm.
Food and beverages are available for purchase. (See menu)